The Becker Lab in October 2015

The Becker Lab

The major aim of our research is to develop novel biomarkers for a more specific diagnosis and therapy of cancer.

Prof. Karl-Friedrich Becker, PhD
Prof. Karl-Friedrich Becker, PhD


Prof. Karl-Friedrich Becker, PhD
Head, Experimental Pathology
Institute of Pathology
Technical University of Munich
Trogerstr. 18
81675 Munich, Germany

Tel.: +49 89 4140 4591
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Analysis of clinical tissue samples

Human tissue samples

The research interest of my group is the anaylsis of molecular alterations in cancer patients. We analyse tissue samples from the clinic at the DNA, RNA, and protein levels in order to detect and characterize disease-associated changes.

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Focus of our research

The Becker Lab on 24 September 2014
  • Quantitative (phospho)protein analysis of clinical tissue samples
  • Development and validation of molecular biomarkers
  • Improvement of tissue quality for diagnosis and research
  • Intratumoral heterogeneity of human cancers


Katrin, Christa und Yasemin

During the last years we were very successful in developing and establishing methods and reagents for mRNA and protein analysis of clinical tissue samples. Very recently, using our innovative techniques we identified a novel subgroup of HER2-negative breast cancer patients that is positive for the activated (phosphorylated) form of HER2. Publication...



My group is partner in various national and international research programs; e.g. we are work package leader in the EU project SPIDIA (Standardisation and improvement of generic Pre-analytical tools and procedures for In-vitro DIAgnostics) and the Munich Leading-Edge Cluster Personalized Medicine and Targeted Therapies M4.



We develop and use unique methods for protein analysis of tissues, e.g. extraction of intact protein from formalin-fixed and paraffin-embedded (FFPE) tissues and Reverse Phase Protein Arrays (RPPA). We termed our approach Liquid Morphology.

On 11-12 April 2013 we organized the very successful 3rd International Workshop on Protein Analysis of Tissues in Munich. Here we demonstrated the generation and use of Reverse Phase Protein Arrays (RPPA). Video...

Go to the people in the lab and our projects.