Our research focuses on molecular and translational aspects of pancreato-biliary carcinogenesis, particularly on largely unknown precursor lesions of cholangiocarcinoma (ITPN, IPNB and BilIN) and pancreatic ductal adenocarcinoma (ITPN and others). By combining morphological expertise and molecular analyses we aim to understand the stepwise tumor progression from non-invasive lesions to invasive carcinomas and to test the hypothesis that distinct pathways of pancreato-biliary carcinogenesis – possibly leading to distinct morphological and prognostic tumor subtypes – exist.
Main interests are:
- Molecular characterization of precursor lesions of bile duct cancer (DFG, in collaboration with Prof. Dr. Irene Esposito
- Prognostic stratification of pancreatic ductal adenocarcinoma
- Surgical pathology of pancreatic ductal adenocarcinoma
- Characterization of neuroendocrine neoplasms (in collaboration with Dr. Björn Konukiewitz)
In collaboration with PD Dr. Moritz Jesinghaus, we investigate the morphology and molecular profiles of epithelial neoplasms of the appendix (goblet cell carcinoids, adenocarcinoma ex goblet cell carcinoid and others) to further understand these unique entities.
This group is part of the Pancreato-biliary and Neuroendocrine Research Cluster.