Systems Biology of Response Prediction in Gastric Cancer

Coordinator: Dr. Julian Mattes

The collaborative research alliance CANCERMOTISYS („Systems biology of drug effects on motility of gastric cancer cell lines“) was supported by the German Federal Ministry of Education and Research (BMBF) and the Austrian Federal Ministry of Science and Research (BMWF) in 2009-2012 within the program Medical Systems Biology – MedSYS. The systems medicine project SYS-Stomach builds on the CANCERMOTISYS project.

The aim of the project was to investigate the efficacy of the therapeutic EGFR antibody cetuximab in gastric cancer cell lines in order to identify molecular biomarkers for response prediction. These biomarkers will be considered in the context of personalised medicine. CANCERMOTISYS addressed questions of systems biology with high medical relevance through an interdisciplinary approach that combined mathematical concepts, computer aided operations and biological experiments.

Partner of the CANCERMOTISYS consortium

Dr. Julian Mattes (Coordinator), Software Competence Center Hagenberg GmbH, Hagenberg, Austria

Swetlana Gaffron, Viscovery Software GmbH, Wien, Austria

Prof. Dr. Rudolf Leube, Institut für Molekulare und Zelluläre Anatomie der RWTH Aachen, Aachen

Prof. Dr. Birgit Luber, Institut für Allgemeine Pathologie und Pathologie der Technischen Universität München

Dr. Dieter Maier, Biomax Informatics AG, Planegg

Dr. Peter Winter, GenXPro GmbH, Frankfurt am Main


Associating approximate paths and temporal sequences of noisy detections: Application to the recovery of spatio-temporal cancer cell trajectories. Dorfer M, Kazmar T, Šmíd M, Sing S, Kneißl J, Keller S, Debeir O, Luber B, Mattes J. Med Image Anal. 2015 Apr 29. pii: S1361-8415(15)00041-9. doi: 10.1016/ [Epub ahead of print] PMID:25987193

Monitoring the cytoskeletal EGF response in live gastric carcinoma cells. Felkl M, Tomas K, Smid M, Mattes J, Windoffer R, Leube RE. PLoS One. 2012;7(9):e45280. doi: 10.1371/journal.pone.0045280. Epub 2012 Sep 27. PMID:23028903

Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines. Kneissl J, Keller S, Lorber T, Heindl S, Keller G, Drexler I, Hapfelmeier A, Höfler H, Luber B. Int J Oncol. 2012 Aug;41(2):733-44. doi: 10.3892/ijo.2012.1479. Epub 2012 May 14. PMID:22614881

Learning cellular texture features in microscopic cancer cell images for automated cell-detection. Kazmar T, Smid M, Fuchs M, Luber B, Mattes J. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:49-52. doi: 10.1109/IEMBS.2010.5626299. PMID:21095879