The Becker Lab
The major aim of our research is to develop novel biomarkers for a more specific diagnosis and therapy of cancer.
Analysis of clinical tissue samples
The research interest of my group is the anaylsis of molecular alterations in cancer patients. We analyse tissue samples from the clinic at the DNA, RNA, and protein levels in order to detect and characterize disease-associated changes.
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Focus of our research
- Quantitative (phospho)protein analysis of clinical tissue samples
- Development and validation of molecular biomarkers
- Improvement of tissue quality for diagnosis and research
- Intratumoral heterogeneity of human cancers
During the last years we were very successful in developing and establishing methods and reagents for mRNA and protein analysis of clinical tissue samples. Very recently, using our innovative techniques we identified a novel subgroup of HER2-negative breast cancer patients that is positive for the activated (phosphorylated) form of HER2. Publication...
My group is partner in various national and international research programs; e.g. we are work package leader in the EU project SPIDIA (Standardisation and improvement of generic Pre-analytical tools and procedures for In-vitro DIAgnostics) and the Munich Leading-Edge Cluster Personalized Medicine and Targeted Therapies M4.
We develop and use unique methods for protein analysis of tissues, e.g. extraction of intact protein from formalin-fixed and paraffin-embedded (FFPE) tissues and Reverse Phase Protein Arrays (RPPA). We termed our approach Liquid Morphology.
On 11-12 April 2013 we organized the very successful 3rd International Workshop on Protein Analysis of Tissues in Munich. Here we demonstrated the generation and use of Reverse Phase Protein Arrays (RPPA). Video...